Yoga is an amalgam of art and science for optimal living that leads to real knowledge of self and mitigates all the miseries of human existence as defined in the noted yogic text- Srimad Bhagavad Gita (6:17). This yogic concept implies the contemporary significance of Mind-body-spirit Interventions (MBSIs) to prevent and moderate worldwide spread psycho-somatic illnesses that cause most of the deaths, distress, poor work performance and economic decline. Yoga has been accepted as one of the most prominent and popular dimensions of Complementary & Alternative Medicine (CAM) and found an inexpensive, generalized and global approach for health promotion, disease prevention, rejuvenation, healing, age reversal (Ornish et al., 2008) and ascetic elevation (Acharya, 2007). The yogic efficacy to lead the journey from illness to wellness, zero to absolute, miseries to ecstasy, diversity to unity and pluralism to holism is experientially and experimentally validated. Samkhya philosophy as the theoretical foundation of Patanjali Yoga Sutras defines yoga as the process for the separation of Purusha and Prakriti, i.e. isolation of Purusha from Prakriti to be established in its real form (Kaivalya). Where Purusha is pure consciousness, immortal, omniscient, omnipresent, omnipotent, blissful, eternal and unchangeable but Prakirti is a balanced state of three strands- sat, raj and tam with features of inertia, eternality, and changeability. The changeability is the function of three strands and the root for all miseries. Ceasing changeability or detachment from Prakriti by yogic/spiritual ways culminates in eternal bliss and peace what everyone is seeking. Importantly, the union of Purusha and Prakriti leads to evolution with subsequent downfalls of ultimate consciousness accompanied with products namely cosmic intelligence (mahat), ego (feeling of self-existence) with three levels- sat, raj, and tam that eventually result in one mind, five each sensory organs and motor organs (from satwik ahamkara) and five subtle elements followed by five elements- cosmos, air, fire, water and earth (from tamsik ahamkara). The journey of Purusha and Prakriti from their primordial states to five tangible elements is evolution. Conversely, yoga is a journey of involution from five tangible elements to primordial states of Purusha and Prakriti till their complete isolation accompanied with subsequent elevations of the lowest consciousness to ultimate consciousness.